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In rats, extensive secretion of glutathione conjugates of ticlopidine by MRP2 altered the bile composition and decreased the biliary secretion of phospholipids, which may contribute to the cholestatic hepatotoxicity of ticlopidine35.
Two extreme cases are exponential growth on glucose and on ethanol, which lead to almost exclusive fermentation with extensive secretion of ethanol and exclusive respiration to carbon dioxide, respectively.
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This leads to extensive chromatin remodeling and senescence-associated secretion of various factors.
Unexpectedly, after injection, the number of surviving hMSCs decreased markedly and the hMSCs underwent extensive apoptosis, which was demonstrated to promote their secretion of TSG-6, partially through the activation of caspase-3.
This is not surprising considering that there is extensive hemorrhage and tissue destruction, caused most probably by the secretion of Apx toxins.
We performed an extensive mutational analysis of the entire human DISP1 gene, required for secretion of all hedgehog ligand(s) and which maps to the HPE 10 locus of human chromosome 1q41, as a HPE candidate gene.
These cells typically undergo extensive changes in protein expression and secretion, resulting in the development of a senescence-associated secretory phenotype (SASP the persistent secretion of pro-inflammatory growth factors, cytokines, chemokines, proteases and extra-cellular matrix components16.
Hypoparathyroidism, inadequate secretion of parathormone.
The secretion of soluble proteins occurs constitutively.
The brain pattern, eye movements and hormone secretion of volunteers were studied while they slept.
Secretion of hCG of four different placental cell lines.
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