Although the percentage of overlapping bindings between RARα and RXRα is not as high as others, the number of genes that could be bound by RXRα/RARα (4554) is the highest, followed by RXRα/PPARα (3468), RXRα/FXR (2019), RXRα/LXR (988), and RXRα/PXR (666), implying the relatively extensive role of these nuclear receptors in regulating hepatic gene expression.
Summary: This paper is part of a set of four paper co-published in the same issue of Cell to highlight the extensive role of competitive endogenous RNA interactions in regulating both normal physiology and tumorigenesis.
The extensive role of particle agglomeration in the lower sections of the fixed bed was demonstrated in the bed voidage data and is evidently tracked as the reaction front moves up through the fixed bed of particles.
We will focus on the extensive role of ERRs in the transcriptional control of metabolic genes involved in the generation and utilization of cellular energy, with a particular emphasis on the impact of ERRs on gene regulation in skeletal muscles and the liver in relation to type 2 diabetes, metabolic syndrome and insulin resistance.
However, the extensive role of immune responses in the mechanism of action of trastuzumab is still not fully understood.
The extensive role of innate immune system was also analyzed and effect of parasitosis upon expression of important molecules such as lectins reviewed.
The well-known lipid regulators including PPARα, FXR, LXR, and PXR bound to almost 50% of RXRα-bound regions suggesting the extensive role of RXRα in regulating lipids.
Given the extensive role of CUL3/KEAP1/RBX1 complex component proteins in other cellular pathways and functions, biological consequences of disruption to these genes certainly extend beyond the NRF2 pathway.
Multiple blaTEM variants were suggested to coexist among 3 clinical isolates indicating extensive role of TEM β-lactamases for resistance against cephalosporins in our patient isolates.
Of course, a true extensive role of purifying selection governing the evolution of these genes is a possibility; but it is also possible that certain classes of genes with particular average selective pressures tend to be involved in complex diseases; or that there has been a human bias towards the inclusion of certain categories of genes in association studies [ 30].
