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When the original key was lost, an extensive reprogramming of car and key was needed.
Our results thus show that extensive reprogramming of the host transcriptome as well as metabolome occurs upon gall midge challenge.
Recent advancements in the rapidly evolving field of cancer epigenetics have described extensive reprogramming of every component of the epigenetic machinery in cancer, such as DNA demethylation.
Adipocyte differentiation is tightly controlled by a transcriptional cascade, which directs the extensive reprogramming of gene expression required to convert fibroblast-like precursor cells into mature lipid-laden adipocytes.
The study revealed extensive reprogramming of the transcriptome and metabolome of RP upon GMB1 infestation leading to an HR that was induced by the generation and release of reactive oxygen species i.e. singlet oxygen and resulted in LPO-mediated cell death.
Based on the results of our study, we conclude that extensive reprogramming of the transcriptome and metabolome occurs in the rice host (RP) upon gall midge (GMB1) infestation leading to an array of events that likely induce hypersensitive response (HR -mediated HR -mediatednce against gall midge.
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Extensive reprogramming and dysregulation of DNA methylation is an important characteristic of pancreatic cancer (PC).
VSELs have abundant open euchromatin and the differentiated cells that arise by asymmetric cell division undergo extensive reprogramming and compaction of chromatin (by DNA methylation) which may result in a dark nuclear appearance, a characteristic of the Adark SSCs [ 19].
It integrates automated protocol execution with computer-based data interpretation to allow reactions to measurement outcomes in autonomous experiments, but at the same time it has been designed to make it as easy as possible to use it for different types of experiments without extensive reprogramming.
Extending this to further instruments would have required extensive reprogramming, therefore significantly limiting the deployability of this approach.
The constitutive activation of NF-κB in our system and the extensive reprogramming at NF-κB target loci provide further support for this data-driven hypothesis.
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