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The α-MSH precursor is also expressed in a subpopulation of neurons within the nucleus of the solitary tract, a nucleus with extensive projections to the PVH [28]; there is, however, doubt about whether those neurons project to the hypothalamus [29], [30].
The dentate hilar region shows calretinin-positive mossy cells with extensive projections to the molecular layer.
From animal experiments, it is known that the vast system of extrastriate and suprasylvian areas comprising the brain's most important networks receive extensive projections from the lateral posterior-pulvinar thalamic complex, including the intralaminar nuclei [65, 66], that were recently reported to be reduced in volume in migraine patients scanned when attack-free [10].
Of these isoforms, cVAS is expressed within a population of hypothalamic neurons with extensive projections to the median eminence [ 6].
Consistent with this, the labeled populations of layer 2/3 neurons studied here had extensive projections to infragranular layers.
This anterior thalamic nucleus also has more extensive projections to the retrosplenial cortex (an indirect route back to the hippocampus) than does the anterior medial nucleus.
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Therefore, because the MeA sends extensive GABAergic projections to the BNST (52), the LC receives dense innervation from the BNST and sends projections directly to the mPOA (53, 54), it is reasonable to speculate that a neural MeA→BNST→LC→mPOA multi-synaptic circuit may underline an indirect pathway which contributes to the psychogenic stress evoked suppression of the GnRH pulse generator.
The extensive intramedullary projections suggest that these E-DEC interneurons of the BOT and the VRG play a significant role in respiration.
6. Gate-control theories hypothesis that the extensive feedback projections in the mammalian pain transmission system serve to inhibit, enhance, or distort feedforward pain information (from nociceptors (pain receptors) to central nervous system).
These neuropeptides (also called the hypocretins) are synthesized by lateral hypothalamic neurons [4], [5] having extensive central projections [6].
There is some evidence that interhemispheric information transfer may be an exclusive attribute of the secondary somatosensory cortex (S2), which receives extensive interhemispheric projections from the contralateral body part [4], [5].
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