H9-derived epicardial cells also demonstrated extensive nuclei-specific staining for WT1 and BNC1 (Fig. 3C), further confirming the expression of these markers at the protein level.
A consequence of this is that extensive anterograde (nucleus to organelle) and retrograde (organelle to nucleus) signalling is required for co-regulation of nuclear and organellar genes that encode proteins working cooperatively in organelles as well as for the general homeostasis of mitochondria.
Two-colour FISH in combination with extensive screening (>10,000 nuclei) seems to be a useful tool to unequivocally identify micrometastatic cells by demonstrating hyperdiploidy and intranuclear chromosomal heterogeneity.
The extensive analysis of nucleus position patterns revealed a (nearly) tetrahedral symmetry of cell distribution (Fig. 5 a d).
As shown in Figs. 6 and 7, in the Sham + V group, aggrecan and Col-II expressions were extensive in the nucleus pulposus and annulus fibrosus, with weak expression of MMP-13, ADAMTS-4, and Col-I compared with the OVX + V, PLF + V, and OVX + PLF + V groups.
First, the surgeries in monkeys were more extensive, including thalamic midline nuclei such as nucleus reuniens.
The α-MSH precursor is also expressed in a subpopulation of neurons within the nucleus of the solitary tract, a nucleus with extensive projections to the PVH [28]; there is, however, doubt about whether those neurons project to the hypothalamus [29], [30].
High nuclear grade, necrosis, extensive papillary architecture, raisinoid nuclei, and frequent mitoses were not seen in oncocytomas.
These results demonstrate that recurrent periods of apnea induce extensive apoptosis in CNS nuclei that control NREM and REM sleep and that eszopiclone is capable of preventing neuronal degeneration in these sites.
eEPCs also show nuclei containing extensive hetero-chromatin and numerous plasma membrane projections.
The individual BDA injections were considerably more extensive, each involving multiple nuclei (Ghashgaei et al. 2007).
