Such modeling approaches for the development of novel implant alloys can be highly beneficial since they offer the possibility of identifying promising compositions without the necessity for extensive experimental test cycles.
Indeed, some of his maxims are still recommended to beginning historians: skepticism about the sources, freedom from deference to established scholars, the necessity of extensive knowledge of the sources before selection can be made, and insistence on arguments supported by extensive evidence.
In summary, our study results underscore that shallow breathing during CT perfusion imaging of the abdomen reduces the necessity for extensive motion correction during post-processing which may minimise artefacts on parametric images and reduce errors in perfusion value calculation.
One possibility involved the replacement of the steel spikes with alternatives made from carbon fibre, although the report underlined the necessity for extensive testing.
Staff time and funds were taxed by the need for extensive training and the necessity of sending staff members in pairs to dangerous neighborhoods.
There is an extensive literature on the necessity of patient participation in collaboration, but no determination of how to attain it [ 40, 41].
Two independently targeted ES clones were injected into blastocysts to generate syngenic C57 knock-in mice, obviating the necessity for extensive backcrossing.
In terms of testing requirements, Helinor Johnston (Heriot-Watt University Edinburgh, UK) emphasized the necessity for extensive characterization of the nanomaterial in a given test medium, since physiochemical properties that drive toxicity may vary dramatically depending on the test system applied.
This strategy obviated the necessity of extensive backcrossing, which would have been required for converting the genetic background of mice generated by targeting the ES cells from 129 mouse strain.
We used the C57 ES cells for targeting the nonsense mutation in to obviate the necessity of extensive backcrossing to obtain syngenic C57 Ppt1-KI mice had we used 129 ES cells.
It is recognized that a balance needs to be found between the need to be interdisciplinary and the necessity of having extensive specialist knowledge in particular areas.A proposal from this workshop is to explore one or more types of cancer over the full scale of their progression, for example glioblastoma or colon cancer.
