Sentence examples for extensive mutations in from inspiring English sources

When multiple rounds of infection take place in an infected individual (e.g., HIV-1 infection in humans), this can lead to extensive mutations in the viral genome.

BAC recombineering [ 24, 25], a BAC mutagenensis method which uses lambda-mediated homologous recombination in Escherichia coli, can be used to efficiently generate extensive mutations in any targeted allele but is an in vivo system requiring special E. coli strains and is a two step procedure that necessitates that the targeted allele be substituted and then replaced with the desired mutation.

In contrast to how little is known in humans, extensive mutation screens in mice reveal a high proportion (40 50%) of autosomal knockout mutations that cause deaths in prenatal stages when homozygous (Mitchell et al. 2001; White et al. 2013).

Extensive mutations are found in immunoglobulin genes of PEL B-cells.

Recognition of constitutional mutation carriers among pheochromocytoma and paraganglioma patients is of clinical importance but in principle requires extensive mutation screenings in a large group of patients – as several genes are involved, and hereditary predisposition is often present in spite of a negative family history.

These more extensive mutations seen after long-term in vivo replication were associated with a change to a tier 2 profile for SHIV-1157ipd3N4.

By analogy to the extensive literature on mutators (and antimutators) in bacteria and yeast, mutations affecting a broad range of processes that impinge on the mutation rate could be responsible for the extensive variation in mitochondrial mutation rates in Geraniaceae.

In our hands, persistent stalling after depletion of FANCJ does not lead to breaks or extensive mutations.

A mitochondrial mutator phenotype has been proposed to account for the accumulation of extensive somatic mutations in clinical tumors [ 17].

The genome analysis of Neurospora crassa and F. graminearum has indicated that the process of RIP, in which duplicated sequences are subject to extensive mutation, may result in the lack of highly duplicated sequences [ 40, 41].

Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma.