Sentence examples for extensive mutation from inspiring English sources

Therefore, we have designed an extensive mutation and copy number variation (CNV) analysis investigating the prevalence of genetic and structural variations in SH2B1 in the Belgian population.

These hosts have adapted to the presence of the virus, which is present at high levels in the host's blood but evokes only a mild immune response, does not cause the development of simian AIDS, and does not undergo the extensive mutation and recombination typical of HIV infection in humans.

Thus, the OncoMap platform provided more extensive mutation information than earlier mutation profiling efforts which focused exclusively on oncogene mutations.

In conclusion, the extensive mutation frequency data summarized in this paper provides a useful context in which mutation prevalence data from population-based surveillance studies of transmitted resistance can be interpreted.

We evaluated extensive mutation data on this surface, that characterized two functionally relevant residues R122 and W127 that resulted in failure to inhibit infection by HIV-1/Δvif due to lack of packaging of APOBEC3G into viral particles.

By subjecting these to extensive mutation and selection (using Stylus see below), genes encoding paths with realistic irregularity (i.e., irregularity that is consistent with a real evolutionary history) are easily produced.

Further extensive mutations of MeuTXKα3 at site 30 could help improve its K+ channel-blocking and antibacterial functions.

Second, more extensive mutations targeting the central appendage either completely disrupted (ΔLQPNP) or reduced (EndoA(Arf -HA) the in vivo function of endophilin-Arf -HA

These more extensive mutations seen after long-term in vivo replication were associated with a change to a tier 2 profile for SHIV-1157ipd3N4.

Consistent with this hypothesis, extensive mutations at interface IV not only reduced the activity of the GM-CSF receptor complex but also that of the IL-3:receptor complex [34].

In contrast, our tier 2 SHIV strains, SHIV-1157ipd3N4 and SHIV-2873Nip, showextensiveive mutations and amino acid deletions throughout the gp160 when reisolated 2.7 and 1 years post-inoculation, respectively, when compared to the parental infectious molecular clones [25].