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While such changes could improve probability of success for de-extinction programs, extensive mismatch between historic and future habitat suitability highlights the potential risks of reviving species that may colonize novel geographic space.
For this reason, this study focused mainly on genes whose transcripts appeared to be preferentially up-regulated in B. pahangi microfilariae; a conservative approach bearing in mind that genes unique to B. pahangi and those with extensive mismatch between the probe and target cDNA sequence may not have been detected in the microarray analysis.
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Our HA sequence analysis also showed that HA sequences from influenza (H5N2) viruses of North American lineage and other viruses with other HA subtypes contain extensive mismatches to the primers used in the LAMP assay (Appendix Figure 2A, B).
Significantly, other small RNA studies have found extensive evidence for mismatch at position 9, which suggests that posttranscriptional modification at this position is common [ 30].
MMS is known to induce extensive SSBs through abortive mismatch repair in nuclear DNA, leading to PARP-1 hyperactivation in the nucleus.
Furthermore, as noted above, supplemental oxygen only benefits areas of V ˙ / Q ˙ mismatch and patients with extensive intra-pulmonary shunt may actually be refractory to this treatment.
In cases of no surgical treatment, spontaneous nerve regeneration is in many cases curtailed by scars, neuroma formation, mismatched nerve fascicles, or extensive splitting of the regrowing axons.
Whilst there is extensive evidence for an effect of mismatches on results from microarray hybridisations, much of this applies to results from short oligonucleotide arrays.
The aim of extensive analysis is to investigate the power mismatch losses in PV array under non-uniform irradiations.
The storage and balancing needs of a simplified European power system, which is based on wind and solar power generation only, are derived from an extensive weather-driven modeling of hourly power mismatches between generation and load.
Qualitative mismatches can arise due to the extensive heterogeneity in workers and jobs, mentioned above, coupled with imperfect information and labor market frictions (Sattinger 2012).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com