In addition, voxel-based morphometric MRI analyses and diffusion tensor imaging (DTI) studies have shown that patients with PDD demonstrate extensive grey matter atrophy and white matter microstructural alterations, respectively within the above cortical regions (Burton et al., 2004; Summerfield et al., 2005; Lee et al., 2010; Song et al., 2011; Hattori et al., 2012; Melzer et al., 2012).
Comparing DTI metrics, the most extensive white matter damage (% of significant voxels within a white matter tract) was detected in right uncinate fasciculus using TR and RD.
Extensive white matter abnormalities in patients with first-episode schizophrenia: A diffusion tensor imaging (DTI) study.
Zhang, X. Y. et al. Extensive white matter abnormalities and clinical symptoms in drug-naive patients with first-episode schizophrenia: a voxel-based diffusion tensor imaging study.
The luminous galaxies we observe are embedded in an extensive dark matter environment.
Most of the studies, have reported extensive grey matter (GM) atrophy, not confined to motor areas [8].
Figure 1 Back-scattered electron image of Acarospora sampled near Zlatna smelter, Romania (Figure3b) showing extensive particulate matter (bright phases) on upper surface and within medulla.
b Fluid-attenuated inversion recovery (FLAIR) series in brain MR imaging showed old basal ganglia infarctions in addition to extensive white matter hyperintensities.
CAA should also be suspected in elderly patients with clinical signs of a progressive encephalopathy syndrome with seizures, in which extensive white matter abnormalities are discovered in brain MRI together with multiple CMBs with lobar and subcortical distribution (Fig. 2).
