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New York had extensive linkages to continental Europe.
The advent of electronic health records, information technology, and large databases (such as administrative and genetic) with the potential for extensive linkages have raised concerns about the security of health information [ 2, 3].
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Extensive linkage disequilibrium indicates that up to 100-fold fewer markers will be needed for whole-genome association mapping in dogs compared with humans.
A region of approximately one megabase of human Chromosome 12 shows extensive linkage disequilibrium in Utah residents with ancestry from northern and western Europe.
However, given the highly correlated nature of the two phenotypes and the extensive linkage disequilibrium (LD) across this region, it is difficult to confirm any disease-specific associations within the MHC.
As expected for two highly inbred and elite crop gene pools, we observed extensive linkage disequilibrium on all chromosomes in both spring and winter barleys (Extended Data Fig. 8).
We categorize and rationalize the extensive linkage between the transcriptional machinery and its product, and provide a framework for future studies.
Although mice are the most widely used mammalian model organism, genetic studies have suffered from limited mapping resolution due to extensive linkage disequilibrium (LD) that is characteristic of crosses among inbred strains.
Regions associated with selective sweeps offer targets for future investigation aimed at identifying genes and alleles underlying the selection and breaking up extensive linkage blocks through recombination.
The genomic structure in the dog is unique, with long haplotype blocks and extensive linkage disequilibrium.
To our knowledge, this is the most extensive linkage analysis for parent-of-origin effects in autism to date.
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