Regions associated with selective sweeps offer targets for future investigation aimed at identifying genes and alleles underlying the selection and breaking up extensive linkage blocks through recombination.
We categorize and rationalize the extensive linkage between the transcriptional machinery and its product, and provide a framework for future studies.
The genomic structure in the dog is unique, with long haplotype blocks and extensive linkage disequilibrium.
To our knowledge, this is the most extensive linkage analysis for parent-of-origin effects in autism to date.
Extensive linkage disequilibrium (LD) mapping has limited the locus to three candidates, CDSN, POSRS1C1 and HLA-C.
Extensive linkage disequilibrium and lower genetic differentiation were found in this region in East Asian and European populations.
Elucidating causative genes and polymorphisms is harder than elsewhere in the genome due to the extensive linkage disequilibrium (LD) across the region.
Extensive linkage disequilibrium (LD) operating in the region [9] [11], as well as marked polymorphism and high gene density, have complicated efforts to fully resolve the roles of HLA and non-HLA genes in MS susceptibility.
Indeed, except for the regulation of complement activation locus where an extensive linkage disequilibrium block contains CFH and related genes [15], the clustering ranged from 0 2 for both groups of AREDS SNPs.
Although the HLA region is known to show extensive linkage disequilibrium (LD) spanning over 7 Mb, only SNPs in the 340-kb region showed strong associations with OA (Figure 2), and SNPs outside of this region did not have significant association.
