The structure-based method requires extensive knowledge of the structure of the substrate and inhibitor, limiting what it can screen for.
However, the requirement for extensive knowledge of these interfaces has generally curtailed this type of method to well-studied and ubiquitous domains, such as the SH3, SH2 and PDZ domains (Encinar et al., 2009; Stein and Aloy, 2010).
Many experts, with extensive knowledge of Construction Industry, take subjective decisions, related to verbal methods of decision making.
As research on volcanic fields and geophysical methods progress, boundary fitting may become better informed by more extensive knowledge of specific field constraints, however, a region definition will always be vital for probabilistic approaches.
But enough of my extensive knowledge of the Paley Center.
Programming in assembly languages requires extensive knowledge of computer architecture.
Frey managed to translate her extensive knowledge of art history into Bunyanesque monuments of endearing klutziness.
Tanta used her extensive knowledge of the loan industry to comment, castigate and above all instruct.
"He has extensive knowledge of our global food categories, our customers and our worldwide operations".
"Darra has got amazing contacts and extensive knowledge of best value.
Buyers and sellers often begin with extensive knowledge of autos and therefore speak a common language.
