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The N-terminal extension mediates dimerization and tetramerization, with extensive interactions and distinct interfaces.
We sought to develop the natural hydrogel matrix fibrin as platform for extensive interactions and continuous signaling by the vascular morphogen ephrin-B2 that normally resides in the plasma membrane and requires multivalent presentation for ligation and activation of Eph receptors on apposing endothelial cell surfaces.
Packing analysis of symmetry related molecules showed that no other monomer-monomer pair will show such extensive interactions and lead to this extent of buried surface area.
Together, these observations are most easily explained by the hypothesis that the catalytic domains have extensive interactions and regulate each other's activities.
A particularly difficult task is to break strong PPI in which two monomers are interlocked through extensive interactions and side-chain mutations are insufficient.
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They are generally ill-designed to facilitate high-order e-learning involving advanced cognitive processes, such as evaluating and creating, which require extensive interaction and collaboration among learners and facilitators in an e-learning environment.
It should be flexibly large enough to be diverse and lively, but small enough to allow for extensive interaction and intensive discussion.
The bone matrix secludes and isolates osteocytes which have an extensive interaction and also connect to other surrounding cells via an elaborate network of dendritic processes which may have the potential to modulate bone resorption [26].
Our method captured the extensive interaction and cross talk between the two pathways.
Gaining a better understanding of zoonotic disease emergence, prevention, and control requires quality basic and applied research, which results from extensive interaction and collaboration among professionals from multiple disciplines.
In addition to ABA auxin and ABA ethylene interactions, ethylene and auxin display extensive interactions (Stepanova and Alonso 2009; Muday et al. 2012).
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CEO of Professional Science Editing for Scientists @ prosciediting.com