Naïve HIS mice display an extensive human IgM-expressing B cell repertoire.
Telomerase, the enzyme that elongates our telomeres, is crucial for cancer development based on extensive analyses of human cells, human cancers, and mouse models.
At the transcriptome level, microarray analysis and RNA-Seq have been used to document global mRNA expression across extensive panels of human cells and tissues (Ramaswamy et al., 2001; Su et al., 2002), and to examine features of RNA regulation, such as alternative splicing (Braunschweig et al., 2013).
Those studies that have been performed are generally restricted to human cell cultures where extensive binding was observed under a variety of treatment conditions (Nagy et al., 2007).
Based on concerns over relatedness to B. cereus-group pathogens, we conducted extensive testing of B. thuringiensis (BT) products and their subfractions using seven human cell types.
Human cell lines were purchased from ATCC.
We use extensive mutagenesis in haploid human cells to identify approximately 2,000 genes required for optimal fitness under culture conditions.
In addition, chemical inhibition of DNA-PKcs results into an extensive accumulation of DSB in human cells.
Exploration of CO signaling in human cells suggests extensive overlap with findings in rodents, yet a recent study in endotoxin challenged volunteers failed to detect clinically important anti-inflammatory effects in vivo [32].
In particular, (Shapira et al., 2009) reported a large-scale analysis of influenza infection of human primary lung epithelial cells, in which they identified PPIs between 10 influenza proteins and 87 human proteins and performed extensive mRNA profiling of the infected human cells.
