Numerous deep grooves in the cerebral cortex, called cerebral fissures, originate in the extensive folding of the brain's surface.
The plateau, which is composed mostly of limestone and basalt, has undergone complicated and extensive folding, faulting, and stream erosion and consequently has abrupt relief, an example of which is the famous Huangguoshu Waterfall near Anshun in the southwest.
The extensive folding coupled to binding observed here likely constitutes an obligate feature of biomolecular interactions involving the central and C-terminal part of Aβ.
Between 15.3 and 6.4 mya, widespread volcanism took place, followed by extensive folding; this process then repeated itself from 18.4 to 13.7 mya during the Miocene.
Extensive folding does not occur in the Drosophila intestine (Fig. 2C), possibly owing to its small size.
Furthermore, it has been demonstrated that CaM binding induces extensive folding not only within the CaM binding domain but also contributes to maintaining the AI domain in the active configuration.
The intracapsular rupture is recognised by the presence of the linguine sign, which is caused by extensive folding of the collapsed shell of the implant (Gorczyca et al, 1994).
However, it has been shown that overexpression of LMNB1 results in abnormal nuclear morphology such as extensive folding, blebbing and lobulation in the nuclear envelope of neuronal cell lines (21).
Flat diapers are not widely available in the U.S., as they require extensive folding before each diaper change.
They observed extensive cuticular folds (4 6 um deep folds, with a density of 1 1.2 folds/um), associated with expansion of the cuticle following the final molt, which could account for some of the size increase (about 6-fold).
