Yet Ruban is mindful of the potential for what he calls "soul sickness", the stew of loneliness, alienation and "spiritual, mental and physical exhaustion" that comes with extensive touring.
The present study represents the most severe cases remitted from primary care with generalised symptoms of exhaustion, cognitive weariness and extensive co-morbidity.
Beeching was told she would need extensive chemotherapy and to expect hair loss, weight gain and exhaustion.
For example, CAR-modified immune cell exhaustion can be induced by the end of extensive expansion program, which is evident by the up-regulation of PD-1, TIM-3, and LAG-3 in CAR T cells (Long et al., 2015).
In addition, as DMD patients suffer from muscle degeneration from their early life, myoblasts undergo extensive division in an attempt to regenerate, which eventually leads to exhaustion of the muscle regenerative potential [ 14- 16].
Inadequate rain and extensive irrigation during cultivation also adversely impact the local ecosystem due to the exhaustion of the water table and reduced water levels in water reservoirs, lakes and rivers.
The idea of using this technique as a fast and reliable method to characterize the exhaustion degree of porous materials is that it does not require any extensive sample preparation, like drying or pulverizing process as in the other techniques.
Despite extensive clinical use, the attributes of CAR co-stimulatory domains that impact persistence and resistance to exhaustion of CAR-T cells remain largely undefined.
