There is an extensive literature in epidemiology and social sciences as to how to estimate age, cohort and period effects.
The value of descriptive epidemiology, extensive environmental investigation, and the hypothesis-generation phase cannot be overemphasized.
There are relatively robust datasets for exposure, well characterized and validated analytical methods for benzene and metabolites in blood and/or urine, an extensive toxicology and epidemiology dataset, and several PBPK models of benzene have been developed.
Future research should conduct more extensive work around the epidemiology of asphyxiation suicides to better describe characteristics of these suicides so that targeted prevention strategies can be implemented.
The various diseases associated with asbestos exposure are then considered in turn, with detailed description and illustration of pathologic features as well as extensive discussion of etiology, epidemiology, differential diagnosis, treatment, and prognosis.
Moreover, many JGIM reviewers are academic general internists with extensive training in clinical epidemiology, health services research, critical appraisal, and biostatistics.
With this study we seek to provide an extensive description of the epidemiology of MC among American Indian and Alaska Native (AI/AN) persons, a subset of the general US population.
