They had selected an extensive domain on both sides of the North River in the vicinity of Fort Orange for van Rensselaer, which extended 24 mile in length, 40 mile in breadth and covered an area of almost 1000 square miles.
A muscular military structure protected the (extensive) domains of the One True God, and a burgeoning population of (male) scribes and clerics set out to protect the new Christian canon from heresy.
Importantly, centromeric heterochromatin and PEV are only observed in organisms that have extensive domains of repetitive DNA at their centromeres.
Yet, we show that the overall conservation and topology of PPI networks are robust to extensive domain shuffling of multidomain proteins as well as to finer details of protein interaction and evolution.
We have also demonstrated that they necessarily present a scale-free topology that is robust to extensive domain shuffling of their multiple domain proteins.
Such asymmetric divergence arises, however, "naturally" at the level of protein-binding sites or domains (through "spontaneous symmetry breaking") and is robust to extensive domain shuffling of multi-domain proteins.
In addition to public database searches we added a thorough hand search of reference sections and the PROQOLID database, resulting in an extensive domain and item pool of physical activity questionnaires.
Therefore, authentic problem scenarios on the basis of extensive domain analyses (curricula analysis, textbook analysis, interview and diary studies, etc.; Eigenmann et al. 2015) were developed.
Recently, other models have been proposed, involving extensive domain swapping and major unfolding of the polymer forming molecules [20,21].
In order to obtain high coverage of domain assignments to the protein sequences coded by the isoforms, we made use of the extensive domain annotations in Gene3D [ 29] a resource that integrates domain assignments from CATH [ 17], Pfam-A (and Pfam-B) [ 30] and Superfamily [ 31].
