Despite extensive research on dengue, many ambiguities lie in the functions on the various DENV proteins.
Therefore, if ZIKV infections occur in a population with DENV (or other flavivirus) background immunity, our data suggest that extensive cross-reactivity in the dengue IgM assay will occur, which could lead to the erroneous conclusion that dengue caused the epidemic.
On the other hand, the criteria for severe dengue fever include extensive plasma leakage, severe bleeding, or severe organ impairment.
However, in dengue-endemic countries, it has been shown that, despite extensive vector control efforts, outbreaks of dengue still occur and the number of cases remains high.
Because of the random nature of dengue and the lack of extensive confirmed notification data, it was difficult to ascribe a Mesocyclops prevalence that correlated with absence of Ae. aegypti and therefore absence of dengue.
For both domestic and global markets, it carried out an extensive evaluation of the potential uptake of dengue vaccines in an initial five-year period following licensure [ 26].
Severe dengue virus (DENV) disease is associated with extensive immune activation, characterized by a cytokine storm.
While weak selective pressure on the envelope (E) protein gene of some dengue viruses is evident (19 ), the most extensive changes in virus genotypes appear to be due to recombination or to possible genetic bottlenecks (16, 17, 20 ).
Despite extensive efforts, there is no specific antiviral treatment approved for dengue until now.
Combined with the campaign's interruption in the early 1970s, the acceleration of uncontrolled urbanization with its associated waste management problems in many Latin American cities contributed to the extensive distribution of Ae. aegypti and the return of dengue virus circulation.
