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CYP2D6 also exhibits extensive copy number variation.
Extensive copy number variation of various genes was identified.
This specific case shows extensive copy number variations, with depletion of whole chromosomes 4, 12 and 16.
Intrachromosomal segmental duplications provide the substrate for non-allelic homologous recombination, facilitating extensive copy number variation in the human genome.
In our species, duplication of the pancreatic AMY2 gene originated the salivary amylase gene (AMY1), which shows extensive copy number variation (Perry et al. 2007).
Genes encoding β-defensins show evidence of birth-and-death evolution, adaptation by amino acid sequence changes, and extensive copy number variation (CNV) within humans and other species.
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The human genome displays extensive copy-number variation (CNV).
The results indicate extensive copy-number variation on the second chromosome of these flies.
High resolution array CGH analysis showed unique yet extensive copy-number variations (CNVs), including insertions, deletions, and more complex changes that involve gain (duplication) or loss (deletion) at the same locus in MSDAC clones (Fig. 3a, Fig. 4).
Aneuploidy and structural variations (SVs) generate cancer genomes containing a mixture of rearranged genomic segments with extensive somatic copy number alterations.
Extensive gene copy number variation may also be explained by unequal crossing over processes.
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