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Extensive cellular and molecular heterogeneity is a common feature of glioblastomas, including multiple alterations in the epidermal growth factor receptor (EGFR) gene that may affect treatment response.
Extensive cellular and molecular characterization revealed that widely diverse hematopoietic neoplasms occur in these mice, which arise from different lineages and represent different stages of lymphocyte development.
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CONCLUSIONS: These results indicate that only minor ultrastructural differences exist between the oldest fiber cells in normal and cataractous lenses, and that the presence of extensive cellular damage and disruptions is not necessary for the generation of nuclear opacities in aged lenses.
It is possible that downregulation of already low levels of ephrinB3 and dissociation of existing EphB3/ephrinB3 interactions through extensive cellular disruption and tissue loss in the cortex of wild-type mice may mimic an injured ephrinB3−/− environment and therefore result in a similar outcome.
Dox mcDNA micelleplexes exhibited extensive cellular uptake and demonstrated anti-tumoral activity.
XJB-Lapachone also induced extensive cellular vacuolization and autophagy at a concentration not observed with unconjugated β-lapachone.
Microscopic examination of Phdp biofilms by microscopy revealed that Phdp biofilm architecture display extensive cellular chaining and also bacterial mortality during biofilm formation in vitro.
We hypothesize that acute and persistent infection of professional immune cells (T-cells, monocytes and macrophages) and non-immune cells (endothelial cells and smooth muscle cells) contributes to a sustained inflammatory response mediated by extensive cellular 'crosstalk' and numerous cytokines/chemokines.
On histopathological analysis, we found extensive cellular hypertrophy and patchy interstitial fibrosis in TG-9 hearts (Fig. 2F) (n = 4).
Both of these tissues are characterised by extensive cellular differentiation and wall deposition.
Glioblastomas display extensive cellular heterogeneity and contain a population of cells with properties characteristic of neural stem (NS) cells [ 2].
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