As expected, cell death was not observed in roots treated with water, and extensive cell death was observed in roots treated with ClsA.
Generally, immune responses to viruses that are noncytolytic or have relatively low cytolytic potential can result in extensive cell death or tissue destruction.
In contrast, the PI stain was taken up by all the cells in rice roots treated with LBA4404/pOsAP2/ERF indicating that extensive cell death has been induced (Fig. 3).
In conclusion, an intrastriatal injection of neurturin is a useful method to protect nigral dopaminergic neurons from extensive cell death in a model of progressive Parkinson's disease, as well as to promote the axonal regeneration and dopaminergic function.
Amiodarone showed moderate toxicity in complete medium but induced extensive cell death in DPBS.
Notably, high compound concentrations (≥10 µM) caused extensive cell death eventually quenching the reporter signal.
As shown, lung epithelial cells ceased to proliferate, but did not succumb to extensive cell death (Figure S2B).
In contrast, thapsigargin (T) induced eIF2α phosphorylation at Ser51, upregulation of grp94 and grp78, extensive cell death and PARP cleavage (Fig. 6E).
Inhibiting IA function caused a dramatic decrease in proliferation and extensive cell death and, vice versa, disrupting proliferation reduced A-type current formation.
Loss of GFP fluorescence was apparent in cells that had received the most potent proapoptotic combination of drugs (PSI/VPA/salubrinal), possibly as a consequence of the partial loss of reporter cells due to extensive cell death.
Indeed positivity for C4BP was mainly observed in the areas with extensive cell death, but it was also found on locations in the border zone and even the non-affected tissue (Figure 3A, B).
