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11– 13 A dynamic disease with a wide clinical spectrum that ranges from an asymptomatic infection to a self-limiting febrile illness to severe dengue and to a life-threatening condition characterized by extensive capillary permeability and shock, 5, 6 dengue is considered the world's most rapidly spreading mosquito borne illness.
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For the mechanism of hypoalbuminemia, decreased synthesis of albumin due to hepatic dysfunction, increased catabolism of protein, albuminuria, decreased intestinal absorption of protein due to poor oral intake, and extensive vascular leakage of serum protein due to increased capillary permeability have been postulated [ 7].
Extensive tissue oedema is characteristic of severe thermal injury, and appears to be related to increased capillary permeability, vigorous fluid resuscitation, and changes in interstitial fluid pressure [ 27].
There is extensive capillary nonperfusion peripherally.
Sepsis is a highly inflamed state, with increased capillary permeability.
The kidney is also highly vascularized, with extensive capillary networks of endothelial cells and pericytes [17].
Right frame: arteries and veins are truncated with extensive capillary nonperfusion in the macula.
Nevertheless, they do not take into account a key parameter, which is pulmonary capillary permeability.
To establish the presence of VILI, we analyzed alveolar capillary permeability and the pulmonary inflammatory response.
Cardiopulmonary bypass is associated with systemic inflammatory response, which can cause increased capillary permeability.
Furthermore, an elevated ANP might encourage the development of IPE because ANP increases capillary permeability [27].
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