Sentence examples for extensive backbone from inspiring English sources

Amino acid substitutions predicted to improve catalysis in design calculations involving extensive backbone sampling were individually tested.

Unlike DNA sequence recognition motifs that rely mainly on major groove read-out, MTERF and ALK motifs locate target sequences and aberrant nucleotides within DNA by resculpting the double-helix through extensive backbone contacts.

Crystal structures showed extensive backbone differences around amino acid sites 165 and 180 that lie near the RBP as well as residue differences in the helix close to where α-2,3 and α-2,6 ligands differ structurally, thereby potentially influencing receptor binding.

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However, a small subset of subjects with extensive N t RTI backbone TDR patterns were likely to experience virologic failure.

Overall, TDRs did not affect virologic response for subjects on a boosted PI by week 48; however, a small subset of subjects with extensive NRTI backbone TDR patterns experienced virologic failure.

The binding interaction is further stabilized through extensive sugar and phosphate backbone interactions mediated by residues in the α-helix as well as a conserved loop within the β-sheet that forms a stabilized hairpin structure upon DNA recognition.

Before extensive degradation of the backbone, other enzymes such as acetylesterases, α-glucuronidases, α-L-arabinofuranosidases, ferulic acid esterases or p-coumaric acid esterases remove side chains and substitutes [ 2, 6- 8].

Linear motifs that use mostly side chains for binding may be amenable to interactions in opposite orientations but those that make extensive contacts using their backbones may be limited to a particular orientation.

crRNA-protein crosslinking studies show extensive contacts between the Csm3 backbone and the bound crRNA.

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