Neurexins are essential presynaptic cell adhesion molecules that are linked to schizophrenia and autism and are subject to extensive alternative splicing.
In rNav1.3 or hNav1.3, extensive alternative splicing sites, such as 12v1, 12v2 and 12v3 (rat), as well as 12v1, 12v2, 12v3 and 12v4 (human) in DI-II intracellular loop were identified to be important for channel kinetics (Thimmapaya et al., 2005).
Six EBNA proteins are expressed from mRNAs produced by extensive alternative splicing.
Unlike their mammalian counterparts, zbeta1 and zbeta2 subunit genes display extensive alternative splicing.
Many of these software were developed to manage the transcriptome of higher eukaryotes, which are characterized by a large number of introns that determine extensive alternative splicing.
Especially transcription factors and signal transducers that act as key regulators in complex, multicellular systems seem to be subject to extensive alternative splicing [ 124, 125, 151].
Bioinformatic and experimental analyses focused on post-transcriptional RNA processing, which revealed extensive alternative splicing events in the adult stage of the parasite.
The studies described here demonstrate that WC1 molecules are encoded by a large, multi-gene family whose transcripts undergo extensive alternative splicing.
Our survey of the Arabidopsis thaliana transcriptome revealed that at least twelve genes associated with the circadian clock are subject to extensive alternative splicing.
Analysis of the dataset generated by this process has shown that for allohexaploid wheat there is no evidence for extensive alternative splicing.
Finally, GPCRs are known to undergo extensive alternative splicing [ 3] that generates multiple transcripts including soluble forms: primers used in this study are located in the 7TM regions and thus might not cover the entire transcript population.
