Sentence examples for extensive affinity from inspiring English sources

Conversely, the development of broadly neutralizing antibodies (bnAbs) in natural HIV-1 infection often requires more extensive affinity maturation.

After extensive affinity purification, we obtained a reagent that, in western blot analysis, revealed a major band at the expected molecular weight (88 kD) in wild-type but not in Vac14 −/− brain (Supplementary Figure S1A).

After extensive washing, affinity-purified complexes were separated by SDS-PAGE and visualized by silver staining (Fig. 2B).

These latter studies have comprehensively described whole-chromosome arm homologies between rainbow trout and Atlantic salmon, and extensive linkage group affinities between the ancestral ray-finned fishes and the duplicated chromosomes in salmon species.

Budesonide, a non-halogenated corticosteroid with a high GR-binding affinity and extensive hepatic first-pass metabolism-limiting (extrahepatic) side effects, may be an attractive alternative.

More extensive details of the affinity propagation algorithm are available in the Frey and Dueck paper [ 23], which described its development.

Morphine is considered the 'gold standard' medication for ITDD systems because of its stability, receptor affinity and extensive experience of using the drug by this route.

Extensive experimentation based on affinity reagents and/or mass spectrometry will be required to establish the protein or peptide biomarkers of blood with the acceptable standard of certainty provided by three independent biophysical or biochemical methods in agreement.

Based on our findings that some CSF-associated B-cell clusters apparently undergo extensive somatic hypermutation (ie, affinity maturation) in the periphery, it is also possible that B cells that have already participated in intrathecal immune stimulation and OCB production can egress from the CNS and undergo antigen-directed restimulation in the periphery.

Extensive mutational and photo-affinity crosslinking studies, as well as more recent X-crystallography approaches, have revealed a common "two-site" mode of ligand binding used by each of these family B receptors.

Coupling high-throughput yeast two-hybrid screens with extensive validation by co-affinity purification, we defined a domain-orientated interactome map.