Exact(7)
More detailed analysis of GI tract malformations in Shh−/− mice has revealed more extensive abnormalities: intestinal malrotation, annular pancreas, duodenal stenosis, abnormal gut innervation, and intestinal transformation of stomach [46].
Mammary-specific LMW cyclin E overexpression induced extensive abnormalities at 2 months, including perturbed architecture, polyploidy, anysocytosis and apoptosis.
However, due to the presence of extensive abnormalities in tumour samples, mean DOC ratio will differ from the nominal ratio of one.
One case demonstrated extensive abnormalities in CD4+ T-cells, including increased tumor necrosis factor (TNF α production from activated rectal lymphocytes [ 5].
In cases with the panencephalitic form of CJD, there is usually significant global atrophy with status spongiosis in grey matter and extensive abnormalities in white matter, correlating with disease duration and severity of cortical atrophy (Mizutani et al., 1981; Carota et al., 1996; Matsusue et al., 2004; Tschampa et al., 2007; Jansen et al., 2009).
There now exists a large body of data to indicate extensive abnormalities in bladder urothelial cell gene expression, function, and signaling in BPS/IC, with many of these abnormalities being found both in patient tissue specimens and in explanted bladder urothelial cells.
Similar(53)
But when these sharp old folks die, autopsy studies often reveal extensive brain abnormalities like those in patients with Alzheimer's.
Mild impairment of attention and concentration may occur in any mental illness where people are anxious and distractible (including psychotic states), but more extensive cognitive abnormalities are likely to indicate a gross disturbance of brain functioning such as delirium, dementia or intoxication.
In addition to finding extensive genomic abnormalities in the CH-ES1 line, we also found that the H1, HS293, HS401 and SIVF-02 lines share the general characteristics of hESCs that have been described by the International Stem Cell Initiative (ISCI) 1 [12].
Conversely, muscle from DNM2-S619L larvae had extensive triad abnormalities (Fig. 1B,D).
TEM analysis revealed the presence of extensive mitochondrial abnormalities, such as swelling, in imatinib-treated mice.
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