Sentence examples for extension of the structural from inspiring English sources
This integration of structural, pharmacological, and chemical information on GPCR ligand interactions enables the extension of the structural GPCR ligand interactome and the structure-based design of novel modulators of GPCR function.
In virtual screening experiments we show that our approach clearly improves enrichment factors with both applied variants of our approach: the extension of the structural similarity measure with background knowledge in the form of a hand-selected relevant substructure or the extension of the similarity measure with background knowledge derived with data mining methods.
The two main contributions of this paper are first a clear formalization of the optimization problem that takes into account the costs of devices and specified fault tolerant level and second an extension of the structural model in order to take into account different operating modes and their specific features.
The sCAsD model is an extension for the structural domain/view of the IFC model, providing professional standardization within the synergy effect of the IFC.
In this paper the extension of the Hamiltonian Structural Analysis (HSA) Method to thin-walled straight and curved beams is presented.
The proposed procedure is based on an extension of the evolutionary structural optimization (ESO) method, which has been successfully applied to several optimum material distribution problems, but not for 3D compliant mechanisms optimization.
Assuming the key role played by the interfaces, the proposed fractal energy approach unifies the influences of all the above parameters, through the introduction of a fractal structural parameter (FSP), which represents an extension of the Gurland's structural parameter.
Data for this evaluation were obtained from patients with active RA who were able, in the opinion of their physicians, to self-inject certolizumab pegol, the only PEGylated anti-TNF treatment, as part of a long-term extension of the Rheumatoid Arthritis PreventIon of structural Damage 2 (RAPID 2) study [ 13].
Provided that the sugar pucker of the dxNs prefers the C3′-endo conformation, it is likely that the lack of complete primer extension is a result of the structural effects of the dxN lesion.
Finally R3 relates to the radius of maximal extension of structural elements of the corona at which density differences between solvent and polymer attached dendrons vanish.
A quantitative comparison between the theoretical model and the experiments requires precise knowledge on the force-extension curves of each of the structural states as well as the unbundling and the helix-to-coil transition free energy costs (ε and μ), which warrants future study and is beyond the scope of this mini-review.
