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Mouse Mups have also been shown to function as pheromone stabilizers, providing a slow release mechanism that extends the potency of volatile pheromones in male urine scent marks.
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To extend the potency of vaccines against infectious diseases, vaccines should be able to exploit multiple arms of the immune system.
They have additionally been demonstrated to function as pheromone stabilizers in the environment, providing a slow release mechanism that extends the effective potency of these volatile molecules in male urine scent marks [6].
Co-administration of clonidine increases the potency and extends the duration of cutaneous analgesia by mexiletine, and the minimal dose of clonidine to intensify the analgesic effect is 0.06 μmol.
Discovery of the novel scaffolds and binding mechanism suggests avenues for extending the interaction surface and improving the potency of a hydrophobic pocket binding inhibitor.
We further extend the model by estimating serum potencies, rather than fixing serum potencies at maximum titers.
To determine whether the observed heart rate effects also occurred with structurally related compounds of varying potency, we extended the study to include a further two lolitrem compounds.
One may then be able to "grow" potency by extending the molecule into the CoA portion of the cofactor and "grow" specificity by extending the molecule into the PEG2 region or the shallow negatively charged groove that we had previously noted.
We further highlight the potency of PCAINs for extending the current capabilities of homology modeling into the 'twilight' and 'midnight' zones [15], [16] of low target-template sequence identity (<30% and <10% respectively), including those from recent CASP experiments [17].
The present results extend the previous findings and indicate that potency appears to be similar across a wide range of doses immediately after resuscitation.
Extending the carbon chain by another atom gave strikingly better potency: compound 5 c, which at 35 μ m, exhibited an approximate 10-fold improvement over the parent fragment 1.
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