In the future, new approaches, such as three‐dimensional (3‐D) drug distribution modeling and the use of multiple drug‐releasing implants, will be used to extend the efficacy of these implants in treating larger tumors more similar to intractable human tumors.
To evaluate the expression and long-term persistence of rAAV2 genes and extend the efficacy of in utero rAAV2 to another species, Sprague-Dawley, the rats were treated in utero at 16 days' gestation with the rAAV2CMVgfp virus.
To extend the efficacy of "Gene Group" analysis of AtPAN, the SVM score can be set by users to identify various TRNs, depending on how large the edges of interested.
Hence, EGCG extended the efficacy of cysteamine in vivo, significantly reducing the mRNA expression of Tnf (P < 0.001) and Cxcl2 (P < 0.01, the Student t test) (Fig. 3 D).
Blocking key molecules on the pathways (mitogen-activated protein kinase, phosphatidylinositide-3 kinase and mammalian target of rapamycin [mTOR]) with agents such as farnesylthiosalycylic acid may extend the efficacy of AIs.
The present study confirms and extends the findings of efficacy and safety of ESL as adjunctive treatment of partial-onset seizures as reported in two prior randomized placebo-controlled trials.
13 This report extends the safety and efficacy data of adalimumab for the treatment of CD for up to 4 years of therapy, from the previously reported results in CHARM and ADHERE, 10– 12 and provides data from the longest duration of follow-up in a clinical trial for CD of any anti-TNF agent.
The present studies were designed to extend the dissimilar efficacy profiles of central administration of a CRF agonist, r/h CRF(1 41), versus a CRF-BP ligand inhibitor, r/h CRF(6 33), into mouse and rat models of energy balance in order to further explore in vivo efficacy of these ligands in two separate animal species.
Benish et al. (2008), however, wish to extend the equal efficacy conclusion to all treatments judged to be bona fide.
Therefore, the development of novel quinolones that retain activity against these mutated enzymes has the potential to greatly extend the clinical efficacy of this drug class.
