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Extending vaccination to boys assuming a 100% vaccine efficacy would lead to a 96% reduction in the remaining burden in both male and female carcinomas (versus screening alone) compared with an 89% reduction assuming base case vaccine efficacy.
This would allow a cost-effectiveness analysis including the incremental benefits associated with the incremental costs of extending vaccination.
Extending vaccination to boys would therefore prevent an additional 3,911 male cases compared with girls-only vaccination (65% reduction).
Genital warts cases not prevented by girls-only vaccination are thus reduced by 58% for female cases and 71% for male cases due to extending vaccination to boys.
Extending vaccination to boys and girls would therefore have the potential to reduce the HPV-related cancer burden in males by 65% versus girls-only vaccination.
We conducted a multicentre epidemiological study to ascertain the prevalence of different genotypes of HPV in young Italian women with normal cytology, with the aim of evaluating the possibility of extending vaccination to older females.
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Phase 3 would have extended vaccination to the general public, he said, "but there's been relatively little clamoring for that".
The ambition is to gradually extend vaccination to all two to 16-year-olds.
A universal effort to extend vaccination coverage to all children began in 1974, when the World Health Organization (WHO) founded the Expanded Program on Immunization (EPI).
In the Veneto Region, an immunization program with 7-valent pneumococcal conjugate vaccine (PCV7) was first introduced in 2001 as an optional vaccination only for newborn at risk (2 3 and 14 months old), then in 2005 the program was extended to offer vaccination to all children.
Extending the vaccination period may therefore result in increased numbers of persons vaccinated after the epidemic has started.
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