In addition, lysines can be mono-, di-, or tri-methylated, whereas arginines can be mono- or di-methylated (symmetrically or asymmetrically), thus greatly extending the complexity of histone modification-dependent gene regulation.
Importantly, UV hypersensitivity resulting from BRG1 inactivation depends on the presence of the checkpoint protein TP53 [ 58], extending the complexity of the involvement of BRG1 in UV-induced DDR.
However, studies of Gene × Environment × Epigenetics further extend the complexity of the experimental designs and create a challenge for selecting the most informative epigenetic readouts that can be feasibly performed to interrogate multiple individuals, exposures, tissue types and toxicity phenotypes.
As such elements extend the complexity that comprise decisions and resulting actions, suitable methods are required for quantitative analysis.
Age-related multi-morbidity further increases the contacts with different disciplines and extends the complexity of interactions, often leading to the fragmentation of healthcare services [ 5, 6].
It therefore extends the complexity of GPCR-signalling, despite the fact that future work will have to proof whether pre-assembled complexes represent a widespread phenomenon.
Accounting for decision processes extends the complexity, as they are multidimensional and process elements need to be regarded as latent constructs (composites) that are not observed directly.
Based on these findings, Samson, Mottron, Jemel, Belin, and Ciocca (2006) proposed to extend the neural complexity hypothesis to the auditory modality.
As above using an in vitro model of chicken response to endotoxin, our data revealed the kinetics of gene networks involved in host response to endotoxin and extend the known complexity of networks in chicken immune response to Gram-negative bacteria such as Salmonella.
We call the reader's attention to the fact that other codes with TC Mmin), MC Mmin) or weight spectrum different from those in Tables 1, 2, 3, and 4 are documented in the literature (see for example [8] and [10]), and they could be used to extend the performance-complexity trade-off analysis performed in thiswork.
