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Modelling, however, is unavoidable when extending outcomes beyond the trial horizon.
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The article concludes with some of the perspectives and challenges ahead for EAFM in relation to the establishment of a co-creation process as a means to integrate and utilise multiple sources of knowledge (policy makers, scientists and stakeholders) achieving extended outcomes moving towards an EAFM.
It is the first to include formula fed infants and to extend outcomes to infant sleep, maternal mental health, and family functioning.
This sample type enables analysis of archived sections that have extended outcome data as well as present day specimens that are routinely processed in a similar manner.
Among the 20 survivors at 6 months, patients with poor outcome (extended Glasgow Outcome Scale scores 1 4) showed a longer total depression period per recording day than patients with good outcome (extended Glasgow Outcome Scale scores 5 7).
Monophasic ptiO2 increases were found only in 2 individuals with good outcome (extended Glasgow Outcome Scale [eGOS] ≥6).
In this paper we seek to contribute to the existing body of research by extending health outcome beyond mortality to focus on both morbidity and health behaviours.
Thus, extending the outcome measures in psychotherapy research from mere pathology to measures of QoL might enhance sensitivity to the patient's well-being and level of functioning.
The current study builds on the work of Schantz et al. (2001) by extending the outcome assessment to include affective state and olfactory function and the exposure assessment to include individual PCB congeners.
Paradoxically, two recent publications investigating similar parameters and extending the outcome evaluation to take home babies (Rienzi et al., 2008; La Sala et al., 2009) resulted in contradicting conclusions about the predictive value of their system.
Outcomes included both maternal and fetal/neonatal health outcomes, as well as outcomes extending into childhood and adulthood, and health service costs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com