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In the previous prediction, the extending from B- to E-EGF orientation induced directly the allostery of Lec domain from S1 to S2 via sequential interactions along the following pathway: First, the extending orientation broke up the interaction network near H region between EGF and Lec domains, followed by the disruption of interaction among residues W1, A28, and E34 via a water molecule.
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Freshmen are introduced to these traditions and to the Aggie spirit at Fish Camp, a four-day extended orientation retreat held during the summer.
Dual CIR with optimized spacer sequences, to provide accessibility and extended orientation, are ideal for surface display of antibody libraries in T lymphocytes.
This allosteric model can be used to interpret the catch bond nature since high force promotes strong and long-lived P-selectin-PSGL-1 interaction by turning EGF domain to extended orientation and then inducing the corresponding allostery of Lec domain.
2. The President's signature on an executive order extending sexual-orientation nondiscrimination protections to employees of all federal contractors.
It was also found that the distribution shifted rightward from S1 to S1' conformation, implying that S1' conformation favors more extended EGF orientation and that the extension of EGF orientation promotes the possibility of allostery from S1 to S1'.
Based on this research, many institutions have directed efforts toward improving the first-year experience by creating programs such as freshman seminars, extended freshman orientation, and common book experiences.
From religious tolerance to abolition and universal suffrage, this value has historically expressed itself in growing American inclusiveness and now is extending to sexual orientation.
Examples are parallel rows of longitudinally aligned platelets, with the orientation extending over several cells (e.g., in Convallaria majalis, shown in Fig. 7i), or rosettes, in which the arrangements of platelets are more or less in radially assembled clusters.
A chain-length independent θplateau is consistent with the grafting of the peptoid chains in the intended orientation extending away from the substrate, and concealing the DOPA anchors.
Those orientations extending beyond the edge of an upper hemisphere projection (OEBEUHP) often have an important influence on both the mean orientation and Fisher constant K, thus affecting simulation results.
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