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By extending guide RNAs to include effector protein recruitment sites, we construct modular scaffold RNAs that encode both target locus and regulatory action.
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The project extends guided group discussion to a new setting and behavior, and supports the view that embedding behavior change in group discussion is potentially a very powerful technique.
In normal cell migration models on 2 dimensional surfaces, cells form a leading lamellipodia from which filopodia extend, guiding the direction of movement.
Some have shown that extending the guide RNA by two nucleotides reduces off-target effects, while in Joung's hands truncatingthe guide RNA reduces off-target mutation rates by up to 5,000 fold.
Intracerebroventricular infusions were performed using a Hamilton syringe attached to PE 50 tubing and an internal guide cannula extending beyond the guide cannula into the lateral ventricle.
More recently, this technique has been extended to guide lung-protective ventilation in patients with acute respiratory distress syndrome [5 8].
The insights from the study on the formation of our 3D-Mn-NPS can be extended to guide the design and fabrication of other nanoporous metals.
Transitivity over each hierarchy extends the guide alignment to all pair-wise comparisons in multi-domain families.
In order to extend the guide star concept for microscopy applications, a key point not properly appreciated before is that fluorescence, being an incoherent process, does not contain information about the aberrations gained by the excitation beam.
Then to derive the ranking order of alternatives from the collective IFPR, we extend quantifier guided non-dominance degree (QGNDD) and quantifier guided dominance degree (QGDD) to intuitionistic fuzzy environment.
The experiences weave in and out of reality, but in every new moment, there is a guide extending a hand, drawing me deeper into the madness.
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CEO of Professional Science Editing for Scientists @ prosciediting.com