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Sirt1 is an NAD-dependent deacetylase which is considered to be important for the lifespan extending effects of CR.
The life span extending effects of DN-Dmp53 are furthermore smaller than the life span extending effects of CR.
We propose a model for the life span extending effects of CR in flies.
In these studies lifespan extending effects were mostly confined to females, unlike the results presented here.
For instance, odours from yeast have been shown to modulate the longevity extending effects of dietary restriction [ 9].
We have previously demonstrated that the life span extending effects of CR are partially mediated by dSir2 [ 7].
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Deletion of SCH9 enhances Rim15-dependent stress responses and extends chronological lifespan [5], similar to the lifespan-extending effects of some mutations in AKT homologues in higher eukaryotes [1], [2].
For example, although some of the CLS-extending effects of CR in budding yeast depend on the induction of oxidative and other stress defenses by Rim15p, CR also extends CLS via an Sch9p, Ras2p and Rim15p-independent mechanism [ 7].
The team's next step is to test whether boosted autophagy can indeed explain the life-extending effects of exercise.
Weiner writes engagingly about other researchers and their work in the field: on so-called Methuselah mutants, creatures that live much longer than the rest of their species; genes like Sir2 (Silent Information Regulator 2), which may be responsible for some of the life-extending effects of extremely calorie-restricted diets; and related proteins, known as sirtuins.
For years, researchers who study aging have chased a dream: a way to mimic the life-extending effects of calorie restriction without the drastic diet.
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