We then extend our refinement algorithms [ 11] to handle this data and use different models of gene duplications and losses to study their effect on the performance of the refinement algorithms.
Here, we build on and extend these refinement methodologies to develop an enhanced set of systematic procedures to modify the in vitro metabolic network model of M. tuberculosis iNJ661 [ 15] and develop a network model that is more consistent with in vivo metabolism during the initial eight-week post-infection period.
The design process can benefit from a model-based and simulation-driven approach, where one starts from an abstract top-level model that is extended via stepwise refinements and design space exploration into a detailed and integrated systems model that can be physically realized.
The improved corrosion resistance was attributed to the absence of the second phase Al2Ca at the grain boundary, microstructural refinement and extended solid solubility, particularly of Al, in α-Mg matrix owing to rapid solidification.
The tool set aims at applications in structural biology that involve protein or nucleic acid structure prediction, refinement, and/or extended conformational sampling.
The second refinement extends the first to capture the trust property.
This refinement extends the previous level by adding the purpose and data sensitivity privacy dimensions to the security policy as discussed in Sect.
We extend the concurrent refinement language Circus [Woodcock, J.C.P. and A.L.C. Cavalcanti, The semantics of Circus, in: ZB2002 LNCS 2002) (2002), pp. 184 203] through integrating continuous time and resource information.
This suggests that B-cell epitope prediction can be systematically developed through iterative refinement extending its applicability to increasingly complex systems, towards the long-term goal of effecting biological outcomes that advance global health [ 10].
The adaptive grid method including the multigrid calculations can be extended to several levels of refinement.
