Sentence examples for extended proliferation from inspiring English sources

Pink color marks the nTSG-like genes, which upon silencing cause overgrowth and extended proliferation in acini and disability to organize symmetric acinar architecture.

Interestingly, hPDMC/Bmi-1 showed extended proliferation after long-term growth arrest and telomerase was activated in the immortal hPDMC/Bmi-1 cells.

We previously showed that PAX3-FKHR expression in primary human myoblasts, cells that can give rise to RMS, cooperated with loss of p16INK4A to promote extended proliferation.

Because DNA damage occurs during normal cellular proliferation, the accumulation of unrepaired DNA damage in hESCs during extended proliferation could lead to genetic instability and thus promote tumorigenesis in cells differentiated from hESCs.

We considered whether the number of unstable divisions during the extended proliferation period available to the explants might have generated sufficient variation to allow the appearance of mutant clones resistant to the effect of our knockdowns.

Third, analysis of embryonic-stem-cell-derived and primary cells reveals that 'weak' CpG islands associated with a specific set of developmentally regulated genes undergo aberrant hypermethylation during extended proliferation in vitro, in a pattern reminiscent of that reported in some primary tumours.

Moreover, BPA extended the proliferation potential of 6/6 primary finite-life HRBEC cultures another effect reduced by curcumin.

Oocyte numbers in the Notch2 conditional mutants were increased not by excess or extended cellular proliferation, but as a result of decreased oocyte apoptosis.

In our complex (developing tissue) system, the real impact of the MSTN mutation is manifest at multiple biological scales: micro- (impaired binding of MSTN to the MSTN receptor ACVRIIB[ 56] at the level of the molecule), intermediate- (extended cell proliferation at the level of the cell) and macro- (gross change in muscle fibre composition and muscle mass at the level of the tissue).

In addition, Yanada et al. suggested bFGF could extend MSC proliferation that can overcome the Hayflick phenomenon.

Consequently, we explored whether 3D culture might provide an opportunity to maintain or extend the proliferation potential of primary cultures.