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Multiple pathways can be illustrated as one extended pathway that better shows the interaction between different biological processes.
North of Red Square is an extended pathway that is home to buildings such as the Intercultural Center (ICC), the Reiss Science building, and the large Leavey Student Center.
MAPK down-regulation is critical for preventing adverse effects of extended pathway stimulation (Hunter 1995).
The extended pathway is subsequently optimised to fit signalling and behavioural data using an Integer Linear Programming formulation.
In this paper we present the construction of "extended" pathway models that aims to explain cellular responses based on pathway activity.
Since a corticosteroid pharmacogenomic pathway, its kinetic/dynamics and TF candidate genes have been partially elucidated, we incorporated these findings and inferred an extended pathway of rat pharmacogenomics.
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These extended pathways also involve the mammillary bodies, the retrosplenial cortex and parts of the prefrontal cortex.
We developed a method for constructing extended pathways that start at the receptor level and via a complex intracellular signalling pathway identify those mechanisms that drive cellular behaviour.
Using the two datasets, we construct "extended" pathways that integrate intracellular activity with cellular responses using a hybrid logical/data-driven computational approach.
Here we presented a method for constructing extended pathways that start at the receptor level and via a complex intracellular signalling pathway identify those mechanisms that drive cellular response.
As a case study, we construct extended pathways for studying hepatocellular carcinoma (HCC), a liver cancer disease that is the third leading cause of cancer death with inadequate therapeutic interventions [ 28, 29].
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