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However, here too, and in the extended ORIGIN analysis (9), there were limitations for definitive interpretation as: (i) there is a rapid drop-off after the median 6.2 year follow-up (arguably too short to evaluate the full effect of exposure on cancer risk); (ii) there was interrupted glargine exposure in the intervention arm and (iii) there was considerable contamination across the arms (10, 11).
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The age of this theropod dinosaur extends the origin of coelurosaurs back into the Middle Jurassic and provides evidence for an early Laurasia-wide dispersal of the Tyrannosauroidea during the late Middle to Late Jurassic.
We have identified a Wnt and a TGF-β gene from the Amphimedon genome, extending the origin of these important gene families to before the divergence of sponge and eumetazoan lineages.
Again, the data presented are more or less linear and extend through origin.
This date predates the oldest fossil record of Desmaninae at 8.2 Myr [ 15] and therefore extends the origin of this clade a few million years back.
The main limitation of this study is that it was confined to a single centre and it would be valuable to extend the origin of the strains.
It can be shown (see [20]) that the function u m can be extended at the origin continuously by using Weierstrass representation.
In the past three decades, our understanding of EOC has been extended into its origin, classification and genetic features.
On the one hand, close family ties in the family of origin, extended family and family of in-laws can result in positive social support for a woman [ 26– 31].
While this is supported by the wide distribution of the single domain ORF in proteobacteria [ 17, 20] a recent issue has potentially extended the putative origin of pepsins (until now restricted to eukaryotes) by describing homologues in oceanic and plant symbiotic bacteria [ 19].
Data was assessed by using two different estimates: 1) provocation dose which increases Rint, EI by 100% (PD100Rint, EI), calculated by interpolation from the last two points of the cumulative semilogarithmic dose-response diagram, and 2) the percent slope (dose-response ratio-DRR) of a line extending from the origin to the last point of the curve (DRR) [ 16].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com