Sentence examples for extended mutations from inspiring English sources

In the conjugative plasmid the zeta and epsilon genes located at the positions of the zeta_2 and epsilon_3 genes in the tetM containing plasmids have obtained extended mutations without affecting the reading frame, and were named zeta_3 and epsilon_3.

Likewise, great molecular heterogeneity in VLCADD [8] makes extended mutation screening obligatory in most cases.

Nonetheless, using food dilution methodologies of CR, several genes have been linked to CR. Life span extending mutations in the insulin receptor substrate CHICO [ 5] were shown to be non-additive to the life span extending effects of CR.

A search of pharmacological modulators of insulin/IGF-1 signaling pathway (which mimetic effects of life span extending mutations or calorie restriction) could be a perspective direction in regulation of longevity.

Further studies are needed to extend mutation detection to the complete ribosomal RNA gene of these species, which will possibly reveal much more about genetic variation in Entamoeba.

The effect of TOR on lifespan operates downstream of the insulin signaling pathway, as indicated by the observation that the increase in lifespan in an insulin signaling mutant cannot be further extended by mutations in components of the TOR pathway [ 21].

Additional testing of extended KRAS/NRAS mutations is recommended.

To ensure complete disruption of miRNA seed sequences in selected non-rescued cases, we extended the mutations to include a complete seed mismatch (position 2 8).

Although most of these life-extending mutations cause crippling side effects, researchers now report that the most potent longevity mutation known leaves flies relatively vigorous.

These similarities suggest that studying interactions between the life-extending mutations and CR may reveal what pathways and mechanisms are utilized by CR to alter aging.

This study implements new analytical approaches to provide a detailed comparison among the effects of life-extending mutations, dietary treatments, gender and aging.