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The partial model obtained from ARP/wARP was extended manually with the help of the program Xfit [57] and was improved by several cycles of refinement, using the program REFMAC [58] and model refitting, followed by the translation-libration-screw (TLS) refinement [59].
Kinase domains were identified by analysis of alignments with the Pfam protein kinase domain, and extended manually as needed.
The knee was flexed and extended manually to ensure thorough distribution of the serum throughout the joint.
After the initial models were built, the remaining parts of the models were extended manually with COOT.
During each passive knee extension trial the knee was extended manually at a constant rate from a flexed position until fully extended.
The base form has been extended manually to different spelling variants, e.g. regulate to regulatory, regulation, etc., the detailed listing of variants is provided in Supplementary file Word_variations.txt.txt
Similar(52)
The search was then extended by manually screening the reference lists of all included papers.
The search was then extended by manually screening the reference lists of included papers.
In addition, the search was extended by manually searching the reference sections of relevant articles; this added 12 publications (See Additional file 2: Table S1).
Outside, a power-operated retractable awning supplants a manually extended one.
We therefore manually extended the data with the corresponding hydrogen mappings within the reaction center.
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