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If she chooses to be screened, it should be in the knowledge that she is accepting the chance of benefit, having her life extended, knowing that there is also a risk of overdiagnosis and unnecessary treatment.
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Wayne Sigler, the longtime director of admissions at Minnesota, likens the task of estimating the right number of admission offers to extend, knowing that many will decline, to that of a captain's steering a large ship.
Artistic directors are appointed to exercise their judgment - a judgment that should extend to knowing when to exit gracefully, as well as how to make your mark.
That belief extends to knowing how to stop Palace's Wilfried Zaha, who failed to score in the clubs' two eventful League meetings this season, from which Watford took four points.
The measures he supports would severely hurt the future of the mortgage industry: What private entity, for instance, would extend mortgages, knowing that Washington politicians would be empowered to change the terms when politically convenient, instead of letting lenders and borrowers see if they could work something out that would take each particular situation into account?
"The issue here is that Nissan knew that they had a faulty radiator and instead of recalling the radiator they extended the warranty knowing that the majority of the cars would surpass 80,000 miles before they started having problems with the transmission," wrote Eva Saldivar of Porterville, Calif., in her complaint to the Center for Auto Safety.
"I think we have to be careful to protect the First Amendment rights of publishers, but free speech does not extend to the knowing facilitation of criminal activity," he said.
They never intended to replicate the existing model online, but hoped to extend its possibilities, knowing, as Jubb puts it, "that it would change, that it couldn't remain the same".
As for free speech, Rob McKenna, Washington State's attorney general, who spearheaded the pressure from his peers on both Craigslist and Backpage, put it clearly: "Free speech does not extend to the knowing facilitation of criminal activity," he said.
Local knowledge can also extend to IRBs knowing local PIs' individual characters, personalities, and past experiences.
Still, time and again, the international financial community has extended Greek credit lines, knowing that Greece wouldn't likely pay them back, to avoid a global contagion after the great recession. .
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com