Further hit confirmation in extended dose-response testing of VLX40 confirmed the relatively higher sensitivity of 8226/Dox40 compared to parental RPMI 8226, the difference in IC 50 being statistically significant (P < 0.05, Students t-test).
Screening assays using 2 different drug concentrations of cell line panels were conducted at Biotox Sciences (San Diego, CA) and extended dose-response assays were conducted at 3-V Biosciences.
If this hypothesis is correct, we would expect the dose response is not uniform across genes, as observed in the extended tails towards better compensation in the distribution of expression change of one-dose genes in one analysis [ 24].
Another thing: pharmaceutical researchers are often looking at something they call "the dose response".
The results are only in male rats, the incidence numbers were very small, and there's no clear dose response.
Most drugs have what's called a dose response function: You take a bigger dose, you get a bigger effect.
A clear inocula dose response was noted.
In silico dose optimizations displayed substantially increased lumefantrine exposures at day 7 and day 14 with the extended dose regimens.
Furthermore, in a large, randomized, controlled multicenter trial comparing low dose and extended dose colchicine regimens, results strongly supported the lower dose colchicine regimen for acute gout [ 15].
Data previously published by our group and others suggest that the use of use of extended dose-dense chemotherapy results in response rates of 40-60% in this otherwise poor prognosis group [ 22- 24].
Our data show that the use of extended dose-dense chemotherapy results in a response rate of 60% in this poor prognosis group, which is consistent with previous published studies (de Jongh et al, 2002; Van der Burg et al, 2004).
