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In the Shh/Shh;hhkr/hhkr double mutants, Nkx2.2, Nkx6.1, Olig2, HB9 and Islet1 were expressed throughout a dorsally extended domain in double mutants, in a pattern similar to hhkr (Fig. 6Q S and data not shown).
This dictated our approach in this paper: rather than focus on mechanistic modelling, we focussed on representative network modules of signalling and considered these in a spatially extended domain, with spatially inhomogeneous signals, both gradual and sharp, of the kind which may be generically expected.
An evolution equation is proposed for δ′ to simulate the ratcheting strain over an extended domain of cycles.
Hence, our data suggest that nucleolar retention of extended-C/EBPα is cell-type independent, requires the RRQR NoLS-motif in the extended domain and is enhanced by phosphorylation of serine 299 within the NLS.
Thus obeys the equation on the extended domain.
The equations are then numerically solved in the extended domain.
Similar(37)
The development of software that can perform extended domain-specific calculations solely from machine-specified semantic relationships is likely to be a long-term project, but implementations such as dREL [13] demonstrate that it is feasible.
The other is to make iterative use of only the lowest order jump conditions to determine the fictitious values on extended domains.
Many significant questions remain concerning the regulatory mechanisms governing such extended domains.
This disorder covers local flexible loops, extended domains, molten globule domains and folded domains with flexible linkers [ 3].
Eukaryotic genomes are organized in extended domains with distinct features intimately linking genome structure, replication pattern and chromatin state.
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