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Extended coordinates build upon the expanded mappings by dividing unassigned regions of the genome between neighboring BACs.
Generating extended coordinates requires expanded coordinates to be calculated first, to allow the most equitable assignment of intervening regions.
Two sets of modified genomic positions are generated for each BAC, which we refer to as expanded and extended coordinates.
Expanded and extended coordinates are computed dynamically based on the BAC membership of the CGH array being worked with.
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We extended the coordinates by 20 kb as per Veyrieras et al. (2008) who showed that approximately 95% of common SNPs likely to affect gene expression reside in the proximal 20 kb to the transcription start and end sites [51].
If the alignment did not include start and stop codons, we extended the coordinates to include the closest upstream ATG start codon and the downstream stop codon.
Human uracil DNA glycosylase (hUNG) follows an extended reaction coordinate for locating rare uracil bases in genomic DNA.
Due to the challenging learning and ethnic situation in the country there is dire need for continued, extended and coordinated activities under the CP 2012-2016.
If this is a true ORF, and the start of APH_1380 is extended to coordinate 1445107, the two putative ORFs APH_1381 and APH_1382 on the positive DNA strand may not be true ORFs, since they are situated opposite coding sequences in the operon and showed no transcription signal (see additional file 7 panel A).
VISOVA displays extend parallel coordinates with group structure.
In order to identify motifs located within or further than 100 kb of a gene, we modified gtf files to extend gene coordinates 100 kb in each direction.
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