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The lifespan of this Rpd3 downregulation was extended consistent with the previous report [ 3] although the content of extension (13% in SFig. 1A-B) was less than the previous observation (33% in [ 3]), which might be explained due to the different genetic background [ 18].
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The onset activity then extended westward, consistent with the expected azimuthal drift of low-entropy plasma brought earthward by the streamer associated flow burst, and then expanded poleward.
cooc310 drives reporter gene expression in segmentally repeated stripes in the germband extended embryo, consistent with the expression of notum, which lies approximately 2 kb downstream of the CRM.
Starvation reduces daf-7 expression in ASI, and laser ablations of ASI extend lifespan, consistent with the role of daf-7 and other ASI-expressed genes in modulating lifespan (Ren et al., 1996; Alcedo and Kenyon, 2004; Bishop and Guarente, 2007).
It is important that the poleward portion of all the identified streamers tilted equatorward as they extended eastward, consistent with them being guided by the large-scale flow poleward of the Harang reversal.
One kinase-mediated extracellular dimer is upright and extended, and consistent with a back-to-back conformation23.
In addition, core probes usually have much stronger signals than extended and full probes, consistent with the design that core probes target high-confidence exons in the genome.
This suggested that ETA might be extended to non-enzymes, consistent with the many experiments where ET guided the functional redesign of non-enzymes [74], [75], [94].
Note that the backbone phylogeny we built using the bootstrap-based extended majority rule was consistent with the species phylogeny inferred in [ 68].
Deceptive pathologic features were defined for T staging by presence of inflammation extending beyond tumor or microscopic spread without inflammation extending to a level consistent with the next stage, and for N staging by large (≥ 10 mm) benign lymph nodes or small (< 10 mm) malignant lymph nodes.
Indeed, a large body of earlier, groundbreaking work showing that calorie restriction [ 10, 11] or down regulation of insulin/IGF-1 signaling [ 12, 13] extends life span is consistent with the observation that down regulation of TOR also extends life span.
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