For example, 44 was found to be >10-fold more potent in the parasite growth assay than the other five extended compounds.
In this work we extend compound class modeling by following not only the concentration of each class but also the average carbon number and variance of the carbon number distribution for each compound class.
Future challenges will focus on the integration of this COD platform with analytical interfaces, to extend compound delivery to multistep processes, and to address biological experiments that cannot be performed in bulk.
In general, if M and N are CL-terms, and I is the interpretation of atomic terms into Pω, then I is extended to compound terms by I MN) = fun(I(M))(I(N)).
This method has also been extended to compound Poisson approximations for the distributions of runs and patterns and Barbour and Chryssaphinou (2001) provides an excellent theoretical review of these approximations.
We show the derivation in more detail in Additional file 2. Further, we extended the compound covariate to multiple gene sets.
A possible precursor of Y is sought in similar manner, and in this way the chain of compounds is extended until a compound, A, is reached that is available for the work; the necessary transformations, beginning with A and ending with Z, are then carried out.
To extend the compound spectrum for hydrolyzable compounds to reservoir temperatures between 100 and 200 °C carboxamides were studied.
