Homologous recombination is the predominant mechanism of repair for double strand breaks during the S-phase and G2-phase of the cell cycle and Brca2 deficiency has been shown to impair cytokinesis and extend cell division [75], [76].
The previous findings that CIP2A physically interacted with c-myc to increase stability, and bind with Plk1 and NEK2 to extend cell division are the possible reasons that inhibition of JNK pathway only partially rescued CIP2A-associated cell proliferation [ 19, 20, 25].
In the 1 D extended model cell divisions are regulated by auxin and a hypothetical morphogen Division Factor.
Remarkably, in cells with fully translocated daughter chloroplasts, the YFP fluorescence extended to the cell division plane between the two daughter chloroplasts and resembled dot-like signals.
Through a yeast two-hybrid library screen, CDKA2 was found to interact with the G2/M-specific CDK scaffolding factor CKS1. Localization of CDKA2 was found to be nuclear in interphase cells, while in cells undergoing cytokinesis, the signal extended to the cell division plane.
In order to model a multicellular system, we extend the previous cell division rule (cell cycle transition from M phase to G1) to produce two distinct cells.
This line of reasoning can straightforwardly be extended to n cell divisions (Rausenberger and Kollmann, 2008): (24) P n (m, t | m 0 ) = ∑ m n, b = 0 ∞ ∑ m n, a = 0 m n, b … ∑ m 1, b = 0 ∞ ∑ m 1, a = 0 m 1, b P 0 (m, t | m n, a ) ∏ i = 1 n − 1 Φ i, where Φ i is a 'probability propagator' of the form (25) Φ i = (m i, b m i, a ) 2 − m i, b P 0 (m i, b, τ | m i + 1, a ), and m n +1, a ≡ m0.
The region of cell division extends over the entire apex, and the RNA content of terminal cells increases.
The zone of cell division extends some distance along the length of the root above the tip region.
Finally, our work also demonstrates a dramatic impact of the lack of epsin on cell division, extending previous observations made in epsin 1 and 2 double KD cells, where abnormal spindles were detected (Liu and Zheng, 2009).
